Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children


 Introduction: Iron overload in thalassemia catalyses the production of a variety reactive oxygen species leading to cumulative cell damage. Ischemia modified albumin (IMA) is an end product oxidative stress. It imperative pick up stress early order prevent organ damage thalassemia. Therefore this study was undertaken estimate IMA levels and see correlation between ferritin establish whether can be proxy marker for stress.
 Methods: A total 76 children were included out which 46 diagnosed cases β- Thalassemia major 30 formed healthy controls. Pre transfusion haemoglobin, AST, ALT, estimated compared with control children. Correlation drawn IMA.
 Results: There significant elevation level as controls (p = < 0.001). positive negative haemoglobin % IMA. Regression relationship established that (ng/ mL) 246.118 + 0.829 (Ferritin ng/dL).
 Conclusions: significantly elevated correlated positively levels. By establishing regression levels, we fairly Hence, utilise instead